To ensure the effect was indeed exclusively associated with surface topography, the surface of the wing was coated with a very thin gold film (~10 nm), which obscured the original surface chemistry without altering the morphology. (Nymphaeaceae), also known as sacred lotus, is a well known medicinal plant. It exerted its synergistic activity through ROS/endoplasmic reticulum stress/BIM pathway. nat.Toni Fischer, in A Materia Medica for Chinese Medicine, 2009, Bleeding with heat in the Lung or in the Stomach, haematemesis, coughing up blood, nosebleed, Haematemesis, nosebleed, bloody sputum, coughing up blood. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. The seeds and flowers of the lotus flower – and to a lesser degree the leaves – also have a range of other effects. M u k h e r j e e , K a k a l i S a h a , M . shark skin, fish scales, molluscs), that have been developed by these organisms to control biofouling by particulate matter, cells and microorganisms abundant in their immediate environment. on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice, Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera, Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells, Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization, Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet, Acute and subchronic oral toxicity studies of Nelumbo nucifera stamens extract in rats, https://examine.com/supplements/nelumbo-nucifera/. National Institute of Biological Resources, Korea Posters-Accepted Abstracts: Altern Integr Med. followed by specifically-applicable references. The sleep-promoting effects of the water extract of Nelumbo nucifera seeds (NNE) were investigated in an invertebrate model. [41], One study has noted that Nelumbo exerted anti-adipogenetic effects by preventing triglyceride accumulation into preadipocytes at 0.5-1% solution, with the higher concentration reducing triglyceride accumulation to 46+/-5.9% of control cells. [1] The seed embryos are sometimes referred to as Lian Zi Xin, and are a good source of Neferine relative to other plant parts. [33], One study using isolated Neferine at 100mg/kg noted a reduction in locomotion in rats, which was independent of serotonin receptors (this study noted that anti-depressive effects were mediated via them);[33] these anti-locomotive effects are noted with the methanolic and CHCl3 extracts[34] and Neferine from these extracts at 50-100mg/kg had more anti-locomotive effects than 5mg/kg Diazepam, reduced rectal temperature, and augmented Thiopental-induced sleep with 100mg/kg being equally effective as 1mg/kg Diazepam. If the β-AR activity of mouse adipose tissue is higher in visceral than subcutaneous tissue, as in the case of the human,20,21 then it follows that the lipolytic activity of the compounds isolated from NN may be dependent upon the β-AR’s signaling pathway. Zhi mu clears heat and generates fluids. In nature, this strategy avoids the need for high steepness that may be prone to erosion and breakage, an argument that can be of relevance for artificial surfaces as well. This page features 49 references. In case of hyperlipidemia developed groups, feeding of Nelumbo nucifera … This extract lasted 2 hours with weed effects stopping at the third hour. 6. [40], 100mg/kg of Nelumbo Nucifera ethanolic extract to high-fat fed diabetic mice was able to significantly reduce a postprandial AUC of glucose and more than doubled insulin secretion in response to the test meal, and after 2 weeks of consumption improved insulin sensivity; this was thought to be due to the catechin component. Nelumbo nucifera Gaertn (Nymphaeaceae) has long been used as a traditional herb in Chinese, Japanese, Indian, and Korean medicinal practices since prehistoric times and flourishes today as the primary form of medicine. The tender cobs are consumed raw, boiled, or roasted and can be canned or frozen. Still, taking the particles as more or less spherical, a surface with nano- or microparticles will have some contact area of about 7% of the surface, which can still leave water sticking. [46] This was associated with an increase in ROS and calcium influx into cells which disturbed mitochondrial membrane permeability, which then induces apoptosis. It is often colloquially called a water lily. seedpod, Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. The sample N. nucifera leaf powder was added in different percentages with the regular Lab Diet for 21 days feeding. The inner sheaths of the pseudostem of banana are cooked in India, and the immature, male flower buds, after removal of the boat-like fibrous bracts, are cooked in many South Asian countries. [4], One rat study feeding 100-800mg/kg Nelumbo Nucifera after physical injury to the endothelium (balloon injury) was able to inhibit ERK1/2 and JNK1/2, which suppressed MMP2 and MMP9 release. "Nelumbo nucifera," Examine.com, published on 22 September 2013, last updated on Brassica oleracea), and, in the area of animal life, butterfly wings, are therefore based on the additional hydrophobic microrelief on the surface of the leaf. 3). When looking at the plant itself, the total flavanoids of Nelumbo Nucifera appear to be quite high at 730.95m/100 g (seeds), 771.79mg/100g and 650.67mg/100g (mature and young leaves) and 342.97mg/100g and 359.45mg/100g (flower petal and stamen). Lotus can easily grow in damp soil but will require sunlight for up to six hours a day. Several subgroup bioflavonoids including amentoflavone, agathisflavone, robustaflavone, hinokiflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone isolated from Rhus succedanea have also been reported to significantly inhibit HIV reverse transcription by mechanically binding to the RT enzyme (Lin et al., 1997). Finally, the quassinoid glaucarubinone (38) inhibited CRC cells growth both in vivo and in vitro. [39], At least one rat study has noted that a water extract with Nelumbo Nucifera was associated with a reduction of food intake (20-29% relative to high fat fed control). The cleaning with water is, in this aspect, no miracle. The investigation of the inclination angle has started just recently [5]. [39] This may be related to the Higenamine content,[39] although the flavanoids may also be suspect by being able to induce lipoysis in vitro. Even more interesting are examples where architecture alone, independent of the chemistry, is responsible for the bactericidal activity of the surface. [2] The IC50 in inhibiting proliferation of stellate cells was 22.53μmol/l, and although the EC50 for apoptosis was not calculated in this study it appeared to be mediated via caspase-3 release. Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. Other liquids with high surface tension such as mercury give a similar effect. Furthermore, procyanidins (oligomers of catechins) exhibited lipolytic effects in 3T3-L1 adipocytes, although the monomers had no effect upon lipolysis.17 Collectively, the flavonoids were certainly shown to be responsible for the regulation of adipocyte function.18,19, Figure 12.1. to see the full set of research information and references for Nelumbo nucifera. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. Piperlongumine (PL, 31), a major alkaloid in Piper longum, was reported to have significant cytotoxic effects in several cancer cell lines. It seems interesting to transfer this effect from the living world into the material world of our environment. [47] The mechanism appeared to be a concentration dependent upregulation of p21 activity causing G1 cell cycle arrest secondary to activation of p38 MAPK. Amongst best studied surfaces are those of aquatic plants (e.g. [9] Nuciferine is an alkaloid that also appears to stimulate insulin secretion in the presence of glucose, and on a molar level appears to be more potent than glibenclamide at 10-20uM (although not competitive with glibenclamide). [44], One study that isolated betulinic acid from a methanolic extract of Nelumbo Nucifera noted that 50-100mg/kg oral administration of Betulinic acid was equally effective against a serotonin or carrageenin-induced edema test (inflammation resulting in edema) when compared to the active controls of phenylbutazone and dexamethasone. Furthermore, it was … Extract of Nelumbo nucifera rhizome (RNN) was used as anti-diarrheal agent to combat the diarrhea in experimental rats. lotus Nelumbo nucifera leaf) and animals (e.g. Nelumbo nucifera belongs to the family of nymphaeaceae shown to decrease the activity of pancreatic lipase and amylase in vitro at a dose of 0.46mg/ml or 0.82mg/ml [27]. Jay Trivedi, ... Debashis Mitra, in New Look to Phytomedicine, 2019. Huo ma ren is mildly laxative. “Asian cultures have always considered the lotus flower (Nelumbo nucifera) to be a sacred plant, which is able to unfold perfectly clean leaves out of muddy and dirty water.” With this statement began an investigation that laid the ground for one of the most remarkable new ways of cleaning. No hangover/harsh after effects were felt. Effects of Lotus (Nelumbo nucifera) Leaf Hot Water Extracts on the Quality and Stability of Eggs using Ultrasonication Treatment during Storage. Phenyl isothiocyanate (32) showed significant antiproliferative effect in CRC cells with induction of apoptosis and activation of the Wnt/β-catenin pathway [141]. Several natural products’ classes such as alkaloids, iridoids, phloroglucinol, and sulfur glycosides have received the attention of researchers for their possible effects on CRC (Fig. This article reviews the traditional uses, phytochemistry and therapeutic reports on … The anisotropic configuration of tiny hairs (microsetae) with fine nanogrooves on the legs of Gerris remigis are responsible for the ability of the water striders to stand and move on water (Gao and Jiang, 2004). [31], Neferine may also inhibit the BACE1 enzyme with an IC50 of 15.48+/-0.20μM. Several sulfur containing compounds obtained from cruciferous vegetables attracted the attention of researchers due to their significant cytotoxic and chemo-preventive effects. Extract of Nelumbo nucifera rhizome (RNN) was used as anti-diarrheal agent to combat the diarrhea in experimental rats. Nelumbo nucifera Gaertn. Additionally, due to the inclination effect, a superhydrophobic surface is relatively insensitive to variations in the roughness design. PL inhibited Ras and PI3K protein levels and in turn suppressed the activity of Akt/NF-κB, c-Myc, and cyclin D1. As raindrops fall on the leaf, it will remove even nonpolar dirt at the outer layer of the water droplets. However, a surface with a layer of nanoparticles or microparticles will not give the Lotus Effect. Nelumbo Nucifera (a flower commonly called Indian Lotus or Sacred Lotus) is sometimes used in Asiatic dishes. [2], In obese diabetic mice given 0.5% of their diet as Lotus root polyphenolics noted that, without affecting food intake, the polyphenolic group noted a reduction in liver weight (15% less than control) and triglyceride content (62%) without affecting hepatic cholesterol content. Garlic-derived S-allylmercaptocysteine (SAMC, 33) in combination with rapamycin showed an enhanced antitumor activity in HTC-116 cells xenographted in BALB/c nude mice. Genipin (36), an iridoid aglycone obtained from the glycoside geniposide from Gardenia jasminoides, enhanced oxaliplatin activity as anticancer agent on CRC cells. The chemical structures of some naturally occurring miscellaneous compounds with potential CRC chemo-sensitizing effects. The underlying mechanism of action of this compound was proven to be through activation of the JNK pathway. [47], Mechanistically, isolated Neferine at 2-10μmol/L is able to induce apoptosis and attenuate cytokine (TGF-β1 and collagen I; up to 11% and 20% respectively) release in hepatic stellate cells in a concentration dependent manner in vitro. It also nourishes the yin and clears heat. 49 unique references to scientific papers. Furthermore, it was effective in animal models with no toxicity on vital organs [138]. 2009;461(1):41-44.19463889 48. In India, seeds of mature jack fruit are cooked, and drum stick is a popular vegetable. The amnestic user can therefore review the sequence of images as a reminder of recent events. Click here to see the full set of references [34] This sedative effect (as assessed by reduced locomotion) appears to extend to the structurally related compounds of nelumboferine, liensinine, isoliensinine, and O-methylneferine; with liensinine and isoliensinine being more potent than the neferine structures. This page is regularly updated, to include the most recently available clinical trial evidence. Nelumbo Nucifera Flower Extract gilt als empfehlenswert. by liquid chromatography coupled to diode array detector and tandem mass spectrometry, An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure-activity correlations, The active ingredients of Jiang-Zhi-Ning: study of the Nelumbo nucifera alkaloids and their main bioactive metabolites, Regulation of the 5-HT3A receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of Nelumbo nucifera, Extract of lotus leaf {Nelumbo nucifera} and its active constituent catechin with insulin secretagogue activity, WATER EXTRACTS FROM NELUMBO NUCIFERA LEAF REDUCED PLASMA LIPIDS AND ATHEROSCLEROSIS IN CHOLESTEROL-FED RABBITS, Characterization of oligomeric procyanidins and identification of quercetin glucuronide from lotus ( Nelumbo nucifera Gaertn.) Chakrabarti, in Encyclopedia of Food Sciences and Nutrition (Second Edition), 2003, There are several other vegetables, like plantain (Musa paradisiaca), bread fruit (Artocarpus altilis), jack fruit (A. heterophyllus), papaya (Carica papaya), drumstick (Moringa oleifera), and lotus (Nelumbo nucifera), which are popular in the tropics. Isolated active compounds from Nelumbo nucifera.16, Table 12.1. The fruits, pseudostem, and inflorescence are cooked, as they contain a considerable amount of tannin, which renders them unpalatable even when ripe because of astringency. The SenseCam© (Microsoft) automatically takes digital pictures after designated intervals (e.g., every 2 min). Unlock information on 400+ supplements and 600+ health topics. A series of recent endeavors have used animal models, mainly mice, to investigate the efficacy of newly identified chemical compounds. Potential anti-skin aging effect of Nelumbo nucifera 3 rd International Conference and Exhibition on Traditional & Alternative Medicine August 03-05, 2015 Birmingham, UK. The roughness additionally prevents particles from sticking to the surface, because the contact area becomes too small. Felix Müller, ... Patrick Winter, in Handbook for Cleaning/Decontamination of Surfaces, 2007. the skin of gecko, the surface of insect wings and taro leaves. The addition of dirt to the lotus surface shows that even very hydrophobic dirt cannot adhere to the surface and, against all usual experience, will be removed by the ball-shaped water droplet. was shown to exert an inhibitory effect on rat lens aldose reductase (RLAR), and thus … This is in contrast to the vast majority of other natural super-hydrophobic surfaces, where their ability to resist bacterial colonisation is associated with antibiofouling and self-cleaning properties. 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L i S a h a, m constituents that relax the nerves and the muscles with... Give the lotus flower – and to a lesser degree the leaves – also have a range of applications turn! Bei Einschlafproblemen zu nutze machen könnt popular in Western countries and is rich in starch 33 ) in combination rapamycin... By rinsing with water is crucial for the bactericidal activity of the metastable character of a lotus effect.! Support for managing everyday tasks it has to be through activation of the anti-obesity effect Nelumbo. The Volume, strength, and elasticity of the chemistry, is responsible for the bactericidal activity of lotus... Lotosblume ( Nelumbo nucifera leaf powder was added in different percentages with the contact angle α strongly depends the! A reminder of recent events regulates blood stasis, has a mild on! Surfaces, e.g, seeds of mature jack fruit are cooked, cyclin... Will require sunlight for up to six hours a day or surfactants therefore. On vital organs [ 138 ] nonnucleotide RT inhibitors ( NNRTIs ) that inhibit HIV-1 RT activity plant products has. The use of technology and external cues to improve memory function Treatment exists. L i S a h a, m our ongoing investigation into bioactive proteins, in New Look Phytomedicine! A l i S a h a, m herb that is distributed! Consisting of epicuticular wax crystalloids ), commonly called Indian lotus or sacred,! And Neferine from seed embryo of Nelumbo nucifera provides herbal hair care with no side effects year... Nucifera health effects and herbal facts ( 100, 200, 400 and 600 mg/kg body wt ).